Jalen Hurts, Miles Sanders, Boston Scott and Kenneth Gainwell each found the end zone on rushes, propelling the Philadelphia Eagles past the Detroit Lions, 38-35, in Week 1 of the 2022 NFL season.
Offensive spotlight: Both teams ran wild amid lackluster passing games. For the Eagles, Jalen Hurts gained 66 yards after contact of his 90 total, and he also forced six missed tackles. For the Lions, D'Andre Swift went well over the century mark and broke six tackles of his own to earn an 80.0-plus rushing grade on first review.
Defensive spotlight: Darius Slay faced a game-high nine targets but allowed only three catches for 55 yards — albeit one for a touchdown. He is still on track to lead Philadelphia's secondary in coverage grade.
Rookie spotlight: Lions preseason standout Malcolm Rodriguez enjoyed a strong debut, although his grade will be hampered by two missed tackles. The linebacker allowed four catches into his coverage for only 24 yards.
Offensive line spotlight: All five Eagles starting linemen earned 69.0-plus pass-blocking grades on first review after allowing a combined six hurries and one sack. Lane Johnson is on track to pace the group in both pass-blocking grade and run-blocking grade.
Betting Summary
| Betting Odds | Closing | Result |
| Spread | PHI -5.5 | DET Covers |
| O/U | 48.5 | Over |
Box Score
Passing
| Philadelphia Eagles | ||||||
| Player | Fantasy | Comp/Att | Yds | YPA | TD | Int |
| Jalen Hurts | 24.72 | 18 / 32 | 243 | 7.6 | 0 | 0 |
| Detroit Lions | ||||||
| Player | Fantasy | Comp/Att | Yds | YPA | TD | Int |
| Jared Goff | 16.5 | 21 / 37 | 215 | 5.8 | 2 | 1 |
Rushing
| Philadelphia Eagles | ||||||
| Player | Fantasy | Car | Yds | YPC | TD | Long |
| Jalen Hurts | 24.72 | 17 | 90 | 5.3 | 1 | 16 |
| Miles Sanders | 18.5 | 13 | 96 | 7.4 | 1 | 24 |
| Kenneth Gainwell | 11.2 | 5 | 20 | 4 | 1 | 7 |
| Boston Scott | 7 | 4 | 10 | 2.5 | 1 | 8 |
| Detroit Lions | ||||||
| Player | Fantasy | Car | Yds | YPC | TD | Long |
| D'Andre Swift | 29.5 | 15 | 144 | 9.6 | 1 | 50 |
| Jared Goff | 16.5 | 2 | 9 | 4.5 | 0 | 10 |
| Jamaal Williams | 16 | 11 | 28 | 2.5 | 2 | 7 |
Receiving
| Philadelphia Eagles | ||||||
| Player | Fantasy | Tgt | Rec | Yds | YPT | TD |
| A.J. Brown | 28.5 | 13 | 10 | 155 | 11.9 | 0 |
| Miles Sanders | 18.5 | 2 | 2 | 9 | 4.5 | 0 |
| Kenneth Gainwell | 11.2 | 4 | 2 | 12 | 3 | 0 |
| Dallas Goedert | 9 | 4 | 3 | 60 | 15 | 0 |
| Zach Pascal | 1.7 | 1 | 1 | 7 | 7 | 0 |
| DeVonta Smith | 0 | 4 | 0 | 0 | 0 | 0 |
| Noah Togiai | 0 | 1 | 0 | 0 | 0 | 0 |
| Detroit Lions | ||||||
| Player | Fantasy | Tgt | Rec | Yds | YPT | TD |
| D'Andre Swift | 29.5 | 3 | 3 | 31 | 10.3 | 0 |
| Amon-Ra St. Brown | 20.4 | 12 | 8 | 64 | 5.3 | 1 |
| Jamaal Williams | 16 | 2 | 1 | 2 | 1 | 0 |
| DJ Chark | 15.2 | 8 | 4 | 52 | 6.5 | 1 |
| T.J. Hockenson | 7.8 | 7 | 4 | 38 | 5.4 | 0 |
| Josh Reynolds | 3.8 | 3 | 1 | 28 | 9.3 | 0 |
| Kalif Raymond | 0 | 2 | 0 | 0 | 0 | 0 |
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