Premium Content Sign Up

Week 2 spread picks for the 2021 NFL season

August 14, 2021; Santa Clara, California, USA; San Francisco 49ers quarterback Trey Lance (5) and quarterback Jimmy Garoppolo (10) warm up before the game against the Kansas City Chiefs at Levi's Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports

Week 1 of the 2021 NFL season is just about in the books. We went 2-1-1 on our picks, getting a push because we were lucky enough to get the New York Jets at +5 (it closed at +3.5). Our lock of the week also hit, as Patrick Mahomes threw three touchdown passes in the second half against the Cleveland Browns.

Week 2 is fast approaching — and with it opportunity to fade overreactions or press reactions that are not strong enough. We’ve already placed a decent number of bets for the slate.


Click here for more PFF tools:

Rankings & ProjectionsWR/CB Matchup ChartNFL & NCAA Betting DashboardsNFL Player Props toolNFL & NCAA Power Rankings


San Francisco 49ers (-3) at Philadelphia Eagles

Point (George Chahrouri): The 49ers closed as 9.5-point favorites in Detroit in Week 1 and dominated to the tune of leading by 21 points entering the fourth quarter. The Lions made a valiant effort to cover, though, dropping the game by a 41-33 scoreline.

Meanwhile, the Eagles put a beatdown on an Atlanta Falcons team that is clearly not very good. While quarterback Jalen Hurts will grade out very well, Philadelphia would be wise not to overreact given its opponent and the fact that Hurts notched only a 3.6-yard average depth of target. Some may be worried that cornerback Jason Verrett tore his ACL, further thinning the 49ers' secondary, but the difference in talent on offense is dramatic. Plus, the 49ers are power-ranked to be six points better than the Eagles, who slot in at 30th.

Fade the Eagles at the top of the market; ride with Kyle Shanahan and his two-quarterback offense.

DOMINATE FANTASY FOOTBALL & BETTING WITH AI-POWERED DATA & TOOLS TRUSTED BY ALL 32

Unlimited Fantasy League Sync
Fantasy Start/Sit Line-Up Optimizer & Waiver Wire
WR-CB & OL-DL Matchups, PFF Player Grades, & Premium Stats 2.0 Tools
Nathan Jahnkes Rankings - #1 Most Accurate Last 70 Weeks
PFF Best Bets, Player Props, & Power Ranking Tools
NFL Mock Draft Sim with Trades & Draft Grades

Already have a subscription? Log In

Betting Featured Tools
  • PFF's Best Bets Tool reveals the bets PFF's data and algorithms give the biggest edge to within spread, total, player prop, and moneyline markets.

    Available with

  • Power Rankings are PFF’s NFL power ratings based on weekly player grades in each facet of play. These power rankings are adjusted based on coach, quarterback and the market each season.

    Available with

Subscriptions

Unlock the 2024 Fantasy Draft Kit, with Live Draft Assistant, Fantasy Mock Draft Sim, Rankings & PFF Grades

$24.99/mo
OR
$119.99/yr